Neurotensin-loaded collagen dressings reduce inflammation and improve wound healing in diabetic mice.

Moura LI, Dias AM, Suesca E, Casadiegos S, Leal EC, Fontanilla MR, Carvalho L, de Sousa HC, Carvalho E., Biochim Biophys Acta., 2014, 1842, 32-43. doi: 10.1016/j.bbadis.2013.10.009. Epub 2013 Oct 23.

Impaired wound healing is an important clinical problem in diabetes mellitus and results in failure to completely heal diabetic foot ulcers (DFUs), which may lead to lower extremity amputations. In the present study, collagen based dressings were prepared to be applied as support for the delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. The performance of NT alone and NT-loaded collagen matrices to treat wounds in streptozotocin (STZ) diabetic induced mice was evaluated. Results showed that the prepared dressings were not-cytotoxic up to 72h after contact with macrophages (Raw 264.7) and human keratinocyte (HaCaT) cell lines. Moreover, those cells were shown to adhere to the collagen matrices without noticeable change in their morphology. NT-loaded collagen dressings induced faster healing (17% wound area reduction) in the early phases of wound healing in diabetic wounded mice. In addition, they also significantly reduced inflammatory cytokine expression namely, TNF-α (p<0.01) and IL-1β (p<0.01) and decreased the inflammatory infiltrate at day 3 post-wounding (inflammatory phase). After complete healing, metalloproteinase 9 (MMP-9) is reduced in diabetic skin (p<0.05) which significantly increased fibroblast migration and collagen (collagen type I, alpha 2 (COL1A2) and collagen type III, alpha 1 (COL3A1)) expression and deposition. These results suggest that collagen-based dressings can be an effective support for NT release into diabetic wound enhancing the healing process. Nevertheless, a more prominent scar is observed in diabetic wounds treated with collagen when compared to the treatment with NT alone.

Chitosan-based dressings loaded with neurotensin-an efficient strategy to improve early diabetic wound healing.

Moura LI, Dias AM, Leal EC, Carvalho L, de Sousa HC, Carvalho E., Acta Biomater., 2014, 10, 843-57. doi: 10.1016/j.actbio.2013.09.040. Epub 2013 Oct 10.

One important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) and N-succinyl chitosan, are presented as potential biomaterials for wound healing applications. Our results show that MPC has the best fluid handling capacity and delivery profile, also being non-toxic to Raw 264.7 and HaCaT cells. NT-loaded and non-loaded MPC dressings were applied to control/diabetic wounds to evaluate their in vitro/in vivo performance. The results show that the former induced more rapid healing (50% wound area reduction) in the early phases of wound healing in diabetic mice. A NT-loaded MPC foam also reduced expression of the inflammatory cytokine TNF-α (P<0.001) and decreased the amount of inflammatory infiltrate on day 3. On day 10 MMP-9 was reduced in diabetic skin (P<0.001), significantly increasing fibroblast migration and collagen (COL1A1, COL1A2 and COL3A1) expression and deposition. These results suggest that MPC-based dressings may work as an effective support for sustained NT release to reduce DFUs

Copyright © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

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Toyo Ink SC Holdings Co., Ltd., the parent company of the Toyo Ink Group, has announced that it has resolved to change its trade name to Artience Co., Ltd. effective January 1, 2024.

According to a press statement, “Artience” is a fusion of the words “art” and “science,” with “art” expressing the stimulation of the five senses and the mind, including the application of colour as well as a liberal arts perspective; “science” represents the application of technology, materials and a rational approach to discovery.

Starting out as a printing ink manufacturer

Headquartered in Tokyo, Toyo Ink SC Holdings Co., Ltd., the parent company of the Toyo Ink Group, is a scientific company with specialty chemicals at its core. Originally starting out as a printing ink manufacturer in 1896, the company is a developer and marketer of its own specialty chemical materials based on functional pigments and polymers.

Talks between Aston Villa and former Lyon manager Remi Garde are due to continue today concerning the vacant managerial position.

The Frenchman as supposed to commentate on the Manchester derby yesterday afternoon for his current employers Canal +, but talks between Garde and Aston Villa prevented him from doing so, according to L’Équipe.

Aston Villa announced the departure of Tim Sherwood at around lunchtime yesterday, but the Villains had been looking for potential replacements long before that point, having already contacted Brendan Rodgers, David Moyes and Remi Garde before Sherwood’s sacking.

Since leaving Lyon in 2014, Remi Garde has rejected several offers, including jobs at Newcastle and very recently at Sunderland. The biggest challenge that Garde faces is ensuring that he can bring and much of his favoured coaching staff with him at such short notice.

Bruno Genesio is somebody that Garde played with at Lyon and was his assistant manager during his spell on OL’s touchline, but Genesio stayed on at Lyon when Garde left and is currently part of Hubert Fournier’s coaching staff. Genesio is vital to Garde’s setup but Lyon are perhaps unlikely to let him leave his current position.

Gérard Baticle and Robert Duverne are the other two individuals that Garde most wants in his potential coaching staff at Aston Villa, but the former is currently employed by Lyon still and Duverne is under contract with Metz.

Duverne of course has already worked for Aston Villa under the orders of Gérard Houllier, between September 2010 and June 2011.

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For Aston Villa, Remi Garde has become a priority because Arsène Wenger has pushed them to go for the former Lyon manager. Wenger has reportedly encouraged Chief Executive Tom Fox and Sporting Director Hendrik Almstadt to appoint Garde, the latter individual of course being a former employee at Arsenal.

If Garde decides to accept the Aston Villa challenge, which will surely depend on how much of his coaching staff he can pull together at such short notice, then he will have a rich array of French/Ligue 1 talent at his disposal. Garde is very much considered by Arsène Wenger as a possible replacement for him at Arsenal, but Remi Garde must prove his credentials in the Premier League first.

Mino Raiola revealed to French radio station RMC that Everton manager Roberto Martinez has told him that he would let Romelu Lukaku go for a fair price.

Raiola had the following to say on the subject:

“Lukaku to PSG? We had a discussion with Martinez, he said he would let him leave Everton if a good offer comes in. But talking about the transfer window now makes no sense.”

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セイコーの発展史、神話の中の鳳凰が灰燼から昇るようで、とても面白いです。1881年、服部と金と太郎は東京市の中心で会社を創設しました。セイコーに的中する1つ目の災難は1923年9月1日の東京の大地震で、セイコー本部、唯一の工場は全く粉砕するに。ごく短い何ヶ月の内で、すでに回復を生産して、その年に11月、セイコーの東京での新聞は広告を掲載して1500匹のセイコーの取引先に向って謝って、彼らの時計は工場に送って保養して、地震の中ですべて壊します。セイコーはこれらに主なを表して全く新しい代替品を受けるように要請します。心からと気前よくその名声を新しい高さに推し進めて、そのためこれはずっとセイコーのブランドの基礎です。

20年後に、１つのもっと大きい災難は訪れて、第2次世界大戦。セイコーの工場は爆撃されてかけら、同じく死傷が無数な経験の従業員があります。あの時果てしなく漠然としているのを望んだけれども、このブランドは依然として堅持して、ゆっくりその生産の施設を再建しておよび、また科学技術方面の人材を育成訓練するのを始めます。でも悪い事の別は1枚セイコーが全く歴史を捨てて0スタートから負担することができるのです。60年代前世紀に入って、その生産の施設は近代化する改造を行って、その競争相手のようだ製造していて過程でおじいさんの世代の骨董の機械を使いを継続しません。これらの新しい生産設置があって、セイコーは気楽にスイスの時間単位の計算の競技を通すことができて、そして1964年の東京のオリンピックのサイクルコンピュータの特許権を獲得します。1965年まで、セイコーは表を作成する世界で最大のオートメーション化の生産ラインを持ちました。

Seiko 62MAS-010

Seiko 6215-010

Seiko 6159-7001

セイコーが潜む水道のメーターに発展してセイコーが試みて品質と性能の方面でスイスの表す策略の中の一つを越えると言うことができます。1965年、セイコーはその第1枚のダイビングの腕時計を製造して、150メートルの水を防ぐ自動腕時計の62MAS―010。2年以降に、セイコーは300メートルの潜む水道のメーターの6215―010を発表しました。1年後に、セイコーは6159―7001発表して、GrandSeiko同じ高周波の自動チップを使いました。

しかし、これらのバージョンを発表した後で、7年間隔を整えて、セイコーはやっと次世代の専門の潜む水道のメーターを発表しました。日本海洋の科学考察人員はセイコー会社に向って助けを求めて、飽和していて潜水して合格の専門のダイビングの腕時計を開発する要請してヘリウムになります。若い徳永の幾の男性の先生は挑戦を受けて、彼は1人のとても能力あるの技師で、この領域で最後に20項の特許を上回って革新を獲得しました。

最後、前回から製品が7年のを出すのがひっそりと静まりかえっていて、1975年、セイコーは有名な専門の600メートルの潜む水道のメーターの6159―022を出しました。それは主に一体化のフライス盤にかけだす表す殻（底のふたでない）のため特徴を設計して、第1枚のチタン合金の潜水する腕時計。もう一つの革新は特許L形の水を防ぐワッシャーで、様々な設計はヘリウムの分子が侵入して殻の内で表しを根絶して、だからセイコーの専門の潜む水道のメーターは瑞士競の品物のようにまた（まだ）設計してヘリウムの閥に並ぶ必要はありません。これはセイコーの“マグロTuna”の腕時計の起源です。
セイコーのデザイナー達は一流な潜む水道のメーターをするのが彼らの会社に対してとても重要だと思って、それが時計が技能の“究極の試練”を作るのためです。１つの潜む水道のメーターは必ず防水でなければならなくて、地震に備えて、とても強い可読性があります。
あの時から、セイコーはその潜む水道のメーターの製品ラインを引き続き改善して、各種の需要を満足させる。基本的なカジュアルの潜む水道のメーターから、セイコーはすでに潜水するコンピュータと石英技術をそのダイビングの腕時計範囲内組み入れました。今たくさんの選択肢があります。その共通の原因は品質と腕時計機能です。さらに加えて近代化する施設の製造技術を有効に利用して、セイコーはすでにそのたくさんの競争相手のなぞらえることができない価格で生産してユニゾンの腕時計があることができました。

その他のシンボル的なセイコーの潜水する腕時計、1996年の出したのSKX007で、およびSKX781、2000年に出した“ダイダイ色の怪物”SKX781。
今日、金と太郎の曾孫、服部の本当の2はセイコー会社CEOとして依然として達するのが完璧なことに力を尽くします。セイコーの潜む水道のメーターはきっと絶えず現れるもっと多くてすばらしい作品があります。

Few movie moments cement a star's everlasting hotness like the moment when Halle Berry emerges from the sea in an orange bikini in the 2002 James Bond movie Die Another Day. From that point on, pretty much no one was allowed to wear an orange bikini ever again because orange bikinis belonged to Berry. But now, 22 years later, Halle Bailey is honoring her first-name twin with a truly respectable Halloween costume of Giacinta "Jinx" Johnson, complete with iconic pixie cut.

Bailey posted a carousel of pictures by photographer Dalvin Adams in which she is absolutely nailing Berry's Bond girl look. In them, she's donning a lookalike orange two-piece—a less wet version—and white tactical belt. But what really seals the deal on making this costume one for the books is the pixie cut.

Berry famously wore her hair very short for years, and Bailey famously has very long locs, but she managed to all of her hair under that teeny-weeny wig—despite some commenters accusing her of using AI or Photoshop to achieve the look. In fact, she even disputed the accusation in her Instagram Stories with a boomerang selfie, writing “lot it wasn't ai the wig really fit

Description

HAYATI PRO MAX BLUE RAZZ LEMONADE NIC SALT E-LIQUID

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• Bottle Size: 10ml
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• VG/PG Ratio: 50/50
• Vaping Style: MTL
• Easy Fill Nozzle
• Childproof Cap

At Hayati, they are dedicated to providing exceptional alternatives to traditional smoking. Their extensive selection includes disposable vape kits and e-liquids, all designed to help smokers make the switch to vaping and prioritize their health. Hayati’s commitment to this mission has never wavered, and they are proud to offer a range of options that are both effective and accessible. With Hayati, you can feel confident and excited about your decision to try vaping as a healthier option.

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Time to read: 1 min

Supply chain disruption is a reality that every company will encounter at some point. The coronavirus outbreak that has spread throughout China is just the latest example of volatility and unpredictability in the manufacturing world, and there will always be more to come. 

However, traditional supply chains are outdated and unprepared to deal with the natural volatility of the world. According to a recent study, 61% of companies say that risks to supply chains have increased over the last year, yet only 14% of companies are adequately moving supply lines based on expected and unexpected risks. Why are companies not planning for disruption? How should they be thinking about a more modernized supply chain, and what steps can they take to get there? 

We’re excited to host a live webinar on March 12th as we bring together industry experts to answer those pressing questions that every company should be responding to. Join Fictiv’s Chief Operating Officer Jean Olivieri, Supply Chain Resources Group Founder Ron Keith, and supply chain and manufacturing journalist Philip Stoten as they walk through the costs of unpreparedness, mitigating that business risk, and how to build a supply chain for the future.

Register here and send in your questions to get the details you need to plan for unpredictability. 

As per January 01, 2023, Weilburger Coatings GmbH will take over the operational business of Paint Systems’ industrial coatings range focusing on the segments automotive and commercial vehicles.

In this cooperation, Paint Systems GmbH, with its many years of know-how in the automotive and automotive supplier industry, is continuing the further development of innovative coating systems with close technical support from Weilburger Coatings.

Strategic expansion of the portfolio

The strategic expansion of the portfolio, especially in the product areas shock absorbers, gas springs, axles, drive shafts, windscreen wipers and other components is thus not only ensured but further expanded through the global sales network of Weilburger Coatings.